![]() ACE2 has a critical role in immune and cardiovascular pathways. ![]() One of the possible explanations about high mortality in hypertensive and cardiac patients may be the function of ACE2 which may derive pulmonary hypertension and cardiovascular complications. Although the mechanism and severity of diseases and their poor outcome are unclear, but some reasons may justify this event. Based on our results, the most hazardous comorbidities in fatal cases were hypertension, diabetes and cardiovascular diseases, respectively. According to various published reports, it is proven that underlying diseases are associated with increased poor outcomes. In the current study, we have conducted a systematic review and meta-analysis to identify the most prevalence underlying diseases in died cases related to SARS-CoV-2 infection. Various reasons like insufficient resources for several cases, prolong incubation time and the most important one presence of comorbidities are known to be associated with high mortality rate. Rapid distribution of COVID-19 all over the world, created a significant burden for health care systems. So, the aim of current study is designed to evaluating the prevalence of underlying diseases in died people with COVID-19.Īs pandemic progress, daily increase in active cases death related to SARS-CoV-2 infection become a global concern. Based on evidences, this information will undoubtedly be key to the knowledge and control of mortality in times of this pandemic. In the current emergency outbreak related to COVID-19, due to the majority of uncertain data around the world, and the lack of certain treatment and vaccine for this infection, it is the time of investigation and research. In fact, these patients have been identified as particularly vulnerable populations for a greater morbidity and mortality when they suffer from COVID-19. Basic analysis about the cause of death have shown critical evidences about the impact of underlying diseases on death related to COVID-19. Since SARS-CoV-2 is a novel virus, little information and majority of uncertainties are present about mechanism of disease which is created a serious threat for infected cases. Further comparative analysis have been revealed that sever form of SARS-CoV-2 may appear in older people which is similar to other respiratory infections such as influenza, severe acute respiratory syndrome (SARS), and Middle East respiratory syndrome (MERS). According to different reports, time range of symptoms progress in COVID-19 death is between 6 to 41 days. Another important factor increasing the risk of mortality in this crisis is the distance between the incidence of disease and hospitalization. According to literature studies, the basic reason for death related to COVID-19 was introduced pneumonia more over it was found that pre-existing morbidities are significantly increase the related mortality rate. Nowadays a well-known reason for death is SARS-CoV-2, although there is no accurate information about mortality rate especially it varies in different countries and reported between 1.4% to 4.3%. Although majority of cases are in mild and moderate and even with no symptoms, but for some infected individuals, the incidence of disease is along with serious complications such as severe pneumonia, acute respiratory distress, multi organ failure and finally death. During less than 9 months, COVID-19 influence on more than 20,000,000 million people and causes 740,000 deaths till now (12 August). ![]() The year 2020 began with a global pandemic, caused by SARS-CoV-2, a highly contagious novel virus which lead a big health challenge in the world.
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